The Dukes are visited by an old friend names Swamp Molly. Molly and Jesse were former moonshine runners together. Molly needs Jesse’s help to make a “final run” that will allow her the finances to help a relative attend divinity school (or something like that). Jesse – known for his integrity – again breaks his vow to never run moonshine again and makes Bo and Luke do it. Rosco busts them in the process where it found they were unknowingly running guns and ammo, not moonshine. An ice cream truck is jumped into a lake. Hijinks ensue.